Oligomeric amyloid‐beta 1–42 inhibits antigen presentation

Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis

Methamphetamine (Meth) is abused by over 35 million people worldwide. Chronic Meth abuse may be particularly devastating in individuals who engage in unprotected sex with multiple partners because it is associated with a 2-fold higher risk for obtaining HIV and associated secondary infections. We report the first specific evidence that Meth at pharmacological concentrations exerts a direct immu...

b2-Adrenoreceptor Agonist Inhibits Antigen Cross-Presentation by Dendritic Cells

Ceramide Inhibits Antigen Uptake and Presentation by Dendritic Cells

Ceramides are intramembrane diffusible mediators involved in transducing signals originated from a variety of cell surface receptors. Different adaptive and differentiative cellular responses, including apoptotic cell death, use ceramide-mediated pathways as an essential part of the program. Here, we show that human dendritic cells respond to CD40 ligand, as well as to tumor necrosis factor-alp...

Differentiation and Antigen Presentation to LILRA2 Activation Inhibits Dendritic Cell

Cilostazol inhibits plasmacytoid dendritic cell activation and antigen presentation.

BACKGROUND Cilostazol, an anti-platelet drug for treating coronary heart disease, has been reported to modulate immune cell functions. Plasmacytoid dendritic cells (pDCs) have been found to participate in the progression of atherosclerosis mainly through interferon α (IFN-α) production. Whether cilostazol influences pDCs activation is still not clear. In this study, we aimed to investigate the ...